Molecular Targeted Therapy

Novel therapeutics for coronary artery disease from genome-wide association study data

BACKGROUND: Coronary artery disease (CAD), one of the leading causes of death globally, is influenced by both environmental and genetic risk factors. Gene-centric genome-wide association studies (GWAS) involving cases and controls have been …

Identification of novel therapeutics for complex diseases from genome-wide association data

BACKGROUND: Human genome sequencing has enabled the association of phenotypes with genetic loci, but our ability to effectively translate this data to the clinic has not kept pace. Over the past 60 years, pharmaceutical companies have successfully …